Team leader

  • Dr. Shiv K. Singh, Ph.D (Max-Eder Group Leader)
    Principal Investigator: Transcriptional Reprogramming in Cancer Plasticity Lab

Team

  • Sinan Önder (MTA)
  • Mengyu Tu (Ph.D. student holding CSC-fellowship)
  • Niklas Krebs (M.D. student holding DGVS-fellowship)
  • Lukas Klein (M.Sc. student)
  • Ekta Sidhu (M.Sc. student)
  • Paul Stahnke (M.D. student)
  • Daniel M. Rodrigues (M.Sc. student)
  • Nazil Serin (M.Sc. student)
  • Veeradinesh Navaratnarajah (M.D. student holding EKFS-fellowship)
Labprofile singh

 

Major Research Interests

One of the major clinical obstacles in the treatment of PDAC is the ability of these tumor cells to metastasize and develop resistance toward standard chemotherapy. Cancer metastasis requires Epithelial-Mesenchymal Transition (EMT), a process accompanied by acquisition of stem cell-like properties in disseminating cells. Of clinical significance, in solid tumors cancer stem cells (CSCs) have been proposed to play a critical role in tumor progression and are considered as a cause of tumor recurrence and resistance to conventional therapy. We have shown that tumor microenvironment influences the transcription factor (TF) networking in the pancreatic cell which determine the aggressive behaviour of tumor cells from non-invasive towards more invasive and metastatic state. Increasing evidence suggests that the tumor microenvironment reconstructs the transcriptional networking which is linked to the squamous or quasi-mesenchymal subtype of PDAC, and is associated with EMT, invasion or stemness properties. The goal of our research work is the identification of novel chromatin regulators and key TFs, which maintain the mesenchymal behaviour, stem cell-like state and drug resistance properties in pancreatic cancer.

forschung umg singh

Representative images show the mutually exclusive pattern of E-cadherin and Sox2 in murine-PDAC progression.

forschung singh2

Model shows that the tumor microenvironment reconstructs the transcriptional network that eventually determine the functional identities of PDAC

 

Scientific collaborations:

  • Dr. Martin Sprick, DKFZ, Heidelberg, Germany
  • Dr. Philipp Rathert, Department of Biochemistry, University of Stuttgart, Germany
  • Dr. Uday Kishore, Department of Life Sciences, Brunel University London, United Kingdom
  • Prof. Stefan Bonn, Center for Molecular Neurobiology, Hamburg, Germany
  • Prof. Shwetal Mehta, Barrow Neurological Institute, Phoenix, USA
  • Prof. Güralp O. Ceyhan, Department of Surgery, Technical University of Munich, Germany
  • Prof. Volker Ellenrieder, Dept. of Gastroenterology & Gastrointestinal Oncology, UMG, Germany
  • PD. Dr. Elisabeth Hessmann, Dept. of Gastroenterology & Gastrointestinal Oncology, UMG, Germany
  • PD. Dr. Dr. Albrecht Neesse, Dept. of Gastroenterology & Gastrointestinal Oncology, UMG, Germany
  • Prof. Steven Johnson, Translational Cancer Research, UMG, Germany
  • Prof. Frauke Alves, Molecular Imaging in Oncology, UMG, Germany
  • Prof. Michael Zeisberg, Division of Nephrology & Rheumatology, UMG, Germany
  • Dr. Ramona Schulz-Heddergott, Institute of Molecular Oncology, Goettingen Center of Molecular Biosciences, GZMB, Germany

Funding

Deutsche Krebshilfe

China Scholarship Council

DGVS

EKFS


Ansprechpartner

Dr. Shiv Singh   [CV | Publikationen]

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Dr Shiv Singh