Research focus

Pancreatitis and pancreatic ductal adenocarcinoma are two pancreatic disorders that pose great challenges for gastroenterologists, immunologists and oncologists likewise. In both disorders inflammatory and neoplastic insults lead to a pronounced activation of the pancreas microenvironment resulting in highly complex transcriptional and biophysical alterations through the activation of a variety of cells such as activated fibroblasts, pancreatic stellate cells, stem cells, inflammatory/immune cells, and a dynamic stromal response. The regulatory function of inflammatory transcription factors (e.g. NFAT) and secreted proteins (e.g. SPARC) within the activated pancreas microenvironment during regeneration and neoplastic transformation is not uniform and may have divergent roles, either disease promoting or restraining. The Neesse laboratory aims to investigate this exciting and emerging field in a combined basic and translational research program. To this end, a broad spectrum of (epi-) genetic, biochemical, transcriptional and pharmacological in vitro and in vivo approaches are employed to dissect the distinct roles of the pancreas microenvironment during pancreatic inflammation and neoplastic transformation. Ultimately, these findings are aimed to contribute to the design of novel and more powerful therapeutics and improved clinical management strategies for patients.

 

 Bei Interesse an Laborrotationen, Bachelor- oder Master- sowie Doktorarbeiten
 Anfrage unter: 0551 39-66343 oder Diese E-Mail-Adresse ist vor Spambots geschützt! Zur Anzeige muss JavaScript eingeschaltet sein!

National and international collaborations

  • Prof. David Tuveson, Pancreatic cancer laboratory, Cold Spring Harbor Laboratory, New York, USA
  • Prof. Hana Algül, Gastroenterology, Technical University Munich, Germany
  • Prof. Duncan Jodrell, Pharmacology and Drug Development, Cancer Research UK Cambridge Institute, UK
  • Prof. Thomas Gress and Dr. Malte Buchholz, Gastroenterology, Endocrinology, Metabolism and Infectiology, University Marburg, Germany
  • Prof. Bence Sipos, Department of Pathology, University Tübingen, Germany
  • Dr. Bart Cornelissen, CRUK/MRC Oxford Institute for Radiation Biology, University of Oxford, UK
  • Prof. Patrick Michl, Gastroenterology and Hepatology, University Halle/Saale, Germany
  • Prof. Anil K Rustgi, Perleman School of Medicine, Department of Medicine, Division of Gastroenterology, University of Pennsylvania, USA
  • Prof. Dieter Saur, Technical University Munich, Germany

FUNDING

ekfs
krebshilfe

 


Ansprechpartner

PD. Dr. Dr. med. Albrecht Neesse

Gastroenterologie und gastrointestinale Onkologie
Universitätsmedizin Göttingen
Robert-Kochstr. 40
37075 Göttingen
Tel.: 0551-39-66343
E-Mail: Diese E-Mail-Adresse ist vor Spambots geschützt! Zur Anzeige muss JavaScript eingeschaltet sein!